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 15-Dic-2005   Stampa la pagina corrente   Mostra la posizione di questa pagina nella mappa

Maria Luisa Brandi

Dipartimento di Medicina Interna
Department of Internal Medicine

She took the MD Degree in 1977, the Board in Endocrinology in 1980 and the PhD Degree in Cell Biology in 1987. She is Full Professor of Endocrinology and Metabolic Diseases, Teacher and Member of the Steering Committee of the Master on “Food Quality and Well-being”, Coordinator of the Master on “Metabolic Diseases of Bone: from the Gene to the Cure” and Director of the Regional Center on Endocrine Hereditary Tumors at the University of Florence. She published over 380 full papers, whose 232 in peerly reviewed journals, as New England Journal of Medicine, Proceedings of the National Academy of Sciences, Journal of Clinical Endocrinology and Metabolism, Journal of Bone and Mineral Research, Human Molecular Genetics,American Journal of Human Genetics, Journal of Cell Biology and JAMA. She is author of 104 books in Cell and Molecular Endocrinology and she released more than 400 invited lectures and seminars at National and International Meetings. She distributed in Italy the publication “Invest in Your Bones” edited by the ”International Osteoporosis Foundation”. She owns 7 patents. Main research fields in human nutrition: Role of minerals in skeletal health; Phytoestrogens as protection factors of menopause complications; Nutritional factors and colon cancer prevention; and Nutrition and kidney stones.
maria luisa brandiProfessore Straordinario di Endocrinologia e Malattie del Metabolismo presso l’Università di Firenze, Responsabile del “Centro Regionale di Riferimento Tumori Endocrini Ereditari”

È Autrice di oltre 300 pubblicazioni in esteso, di cui 210 su riviste internazionali con “peer review”, tra cui New England Journal of Medicine, Proceedings of the National Academy of Science, Journal of Clinical Endocrinology and Metabolism, Journal of Bone and Mineral Research, Human Molecular Genetics, American Journal of Human Genetics, Journal of Cell Biology.

Il suo IF (Impact Factor) globale è superiore a 1000.

Ha svolto oltre 400 letture e seminari su invito a Congressi Internazionali e Nazionali.

È stata Autrice di 86 libri, in tema di Endocrinologia Cellulare e Molecolare

Ha ricevuto numerosi premi quali: Premio Roussel Italia, The European Osteoporosis Foundation Award, Premio Schering of the Italian Endocrine Society, The Sandoz Foundation for Gerontologic Research Award, Helena Rubinstein Award Women in Science.

È membro del Comitato Editoriale di numerose riviste e del Comitato Direttivo e Scientifico di numerose organizzazioni e Società Scientifiche, tra cui la International Osteoporosis Foundation, la Società Italiana dell’Osteoporosi, l’International Committee on Multiple Endocrine Neoplasia Syndromes.

Ha ricevuto numerose citazioni quali: J.A.M.A, Women in Science NIH, Who's Who in the World, Who's Who in Science and Engineering, Who’s Who in Medicine and Health Care, On-Going Research in Cancer Epidemiology, International Agency for Research on Cancer, Who’s Who The Europe 500.

È rappresentante dell’Università di Firenze all’interno del Consorzio PROGEN e Delegato del Rettore per i rapporti con gli Stati Uniti d’America.

Ha prodotto autonomamente 6 linee cellulari continue e clonali da mammiferi (WRT, PTR, BPE, HPE, BBE; FLG 29.1), quando uno sola potrebbe rappresentare per se un traguardo di grande prestigio per un ricercatore.

È signataria di 7 brevetti Internazionali di cui 3 per lo sviluppo di nuovi modelli cellulari di colture continue.

Ricerca attuale e metodologia usata

• Studi Clinici e di Base su Malattie Metaboliche dell’Osso
• Studi Clinici e di Base su Malattie Paratiroidee
• Neoplasia Endocrina Multipla
• Bone Cell Biology
• Endocrine Cell Biology
• Genetica di Malattie Metaboliche ed Endocrine
• Biologia Molecolare e Recettore Estrogenico
• Genetica dell’Osteoporosi
• Stem Cell Biology
• Tumorigenesis del Cancro del Colon
• Clinical Trials nell’Area dell’Osteoporosi
• Sindrome da Ipercalciuria Primitiva.

Elementi di interesse relativi all'alimentazione

• Professore Straordinario di Endocrinologia dal 2000
• Membro del Dottorato di Ricerca in Scienze Fisiologiche e Nutrizionali
• Già Coordinatrice Nazionale di un Progetto Nazionale Cofinanziato 1999-2001 su “Strategie per la valutazione degli effetti disruptivi dei contaminanti ambientali sul sistema endocrino degli animali e dell’uomo”
• Esperta nel settore dei meccanismi di azione di molecole estrogeniche, inclusi i fitoestrogeni, in modelli animali “in vitro” e “in vivo”.

Pubblicazioni selezionate:

• Brandi ML, Fitzpatrick LA, Coon HG, Aurbach GD: Bovine parathyroid cells: cultures maintained for more than l40 population doublings. Proc Natl Acad Sci USA l986; 83:l709.
• Brandi ML, Aurbach GD, Fitzpatrick LA, Quarto R, Spiegel AM, Bliziotes MM, Norton JA, Doppman JL, Marx SJ: Parathyroid mitogenic activity in plasma from patients with multiple endocrine neoplasia type I. New Engl J Med l986; 3l4: l287.
• Brandi ML, Aurbach GD, Fattorossi A, Quarto R, Marx SJ, Fitzpatrick LA. Antibodies cytotoxic to bovine parathyroid cells in autoimmune hypoparathyroidism. Proc Natl Acad Sci USA. l986; 83: 8366.
• Sakaguchi K, Santora A, Zimering M, Curcio F, Aurbach GD, Brandi ML: Functional epithelial cell line cloned from rat parathyroid glands. Proc Natl Acad Sci USA l987; 84: 3269.
• Brandi ML, Marx SJ, Aurbach GD, Fitzpatrick LA: Familial multiple endocrine neoplasia type I. A new look at pathophysiology. Endocr Rev l987; 8: 391.
• Streeten EA, Ornberg R, Curcio F, Sakaguchi K, Marx SJ, Aurbach GD, Brandi ML: Cloned endothelial cells from fetal bovine bone. Proc Natl Acad Sci USA 1989; 86: 916.
• Friedman E, Sakaguchi K, Bale AE, Falchetti A, Streeten E, Zimering M, Weinstein L, Mc Bride WO, Nakamura Y, Brandi ML, Norton JA, Aurbach GD, Spiegel AM, Marx SJ: Clonality of parathyroid tumors in familial multiple endocrine neoplasia type I. New Engl J Med 1989; 321:213.
• Gattei V, Bernabei PA, Pinto A, Bezzini R, Ringressi A, Formigli L, Tanini A, Attadia V, Brandi ML: Phorbol ester induced osteoclast-like differentiation of a novel human leukemic cell line (FLG 29.1). J Cell Biol 1992; 116:437.
• Falchetti A, Bale AE, Amorosi A, Bordi C, Cicchi P, Bandini S, Marx SJ, Brandi ML: Progression of uremic hyperparathyroidism involves allelic loss on chromosome 11. J Clin Endocrinol Metab. 1993; 76:139.
• Brandi ML, Weber G, Svensson A, Falchetti A, Tonelli F, Castello R, Furlani L, Scappaticci S, Fraccaro M, Larsson C: Homozygotes for the autosomal dominant neoplasia syndrome (MEN I). Am J Hum Genet 1993; 53:1167.
• Fiorelli G, Gori F, Petilli M, Tanini A, Benvenuti S, Serio M, Bernabei P, Brandi ML: Functional estrogen receptors in a human preosteoclastic cell line. Proc Natl Acad Sci USA. 1995; 92:2672.
• Brandi ML, Hukkanen M, Umeda T, Moradi-Bihendi N, Bianchi S, Gross SS, Polak JM, MacIntyre I: Bidirectional regulation of osteoclast function by nitric oxide synthase isoforms. Proc Natl Acad Sci USA. 1995; 92:2954.
• Gennari L, Becherini L, Masi L, Mansani R, Gonnelli S, Cepollaro C, Martini S, Montagnani A, Lentini G, Becorpi AM, Brandi ML: Vitamin D and estrogen receptor allelic variants in Italian postmenopausal women: evidence of multiple gene contribution on bone mineral density. J Clin Endocrinol Metab 1998; 83: 939-944.
• Gennari L, Becherini L, Mansani R, Masi L, Falchetti A, Morelli A, Colli E, Gonnelli S, Cepollaro C, Brandi ML: FOK I Polymorphism at translation initiation site of the vitamin D receptor gene predicts bone mineral density and vertebral fractures in postmenopausal italian women. J Bone Min Res. 1999; 14:1379-1386.
• Fiorelli G, Picariello L, Martineti V, Tonelli F, Brandi ML: Functional estrogen receptor  in colon cancer cells. Bioch. Biophys. Res Comm 1999; 261:521-527.
• De Feo L, Colagrande S, Biagini C, Tonarelli A, Bisi G, Vaggelli L, Borrelli D, Cicchi P, Tonelli F, Amorosi A, Serio M, Brandi ML: Parathyroid glands: combination of 99mTc MIBI scintigraphy and US for demonstration of parathyroid glands and nodules. Radiology 2000; 214:393-402.
• Reginster JY, Minne HW, Sorensen OH, Hooper M, Roux C, Brandi ML, Lund B, Ethgen D, Pack S, Roumagnac I, Eastell R, on behalf of the VERT Study Group: Randomized trial of the effects of Risedronate on vertebral fractures in women with established postmenopausal osteoporosis. Osteoporosis Int 2000; 11:83-91.
• Becherini L, Gennari L, Masi L, Mansani R, Massart F, Morelli A, Falchetti A, Gonnelli S, Fiorelli G, Tanini A, Brandi M.L: Evidence of a linkage disequilibrium between polymorphisms in the human estrogen receptor alpha gene and their relationship to bone mass variation in postmenopausal Italian women. Hum Mol Genet 2000; 9:2043-50.
• Masi L, Becherini L, Gennari L, Amedei A, Colli E, Falchetti A, Farci M, Silvestri S, Gonnelli S, Brandi ML: Polymorphism of the aromatase gene in postmenopausal Italian women: distribution and correlation with bone mass and fracture risk. J Clin Endocrinol Metab 2001;86: 1-7.
• Brandi M.L, Gennari L, Matucci Cerinic M, Becherini L, Falchetti A, Masi L, Gennari C, Reginster JY: Genetic markers of osteoarticular disorders: facts and hopes. Arthritis Res 2001; 3:270-280.
 

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